Hi @Schwalb,
You might be interested by this thread :
I’ve managed to get a usable tone with only a x42-eq - Parametric Equalizer and a distortion plugin that’s on the bright side, not muddy (eg : CollisionDrive or GxSD2Lead). As with most amp sims, it sounds quite horrible until you add a cab sim. I’m not saying it does exactly the same as an amp simulator but the whole sounds good. The Pareto Principle seems to work here.
However, I don’t use this pedalboard because the Onyx amp sim is versatile, sounds good and doesn’t use more CPU than the Eq alone.