Hi Kopplog, I’m pretty sure that using the Portal plugin will solve your problem. You have to go straight from your cabsims in the mixer and in parallel send some signal via a Vol plugin in the Portal in (for each channel) .
Then Portal out → Mverb (mix 100%) → mixer.
Have a look here:
And in this pedalboard you should probably replace the mixer by a Xfade plugin ( less CPU hungry )
The pops and dropouts are probably due to the fact that you are maxing out the cpu. You have several items there that will use quite a lot of cpu - the amps and cab emulators can be heavy, and I remember hearing that the mixer can be cpu heavy. Try removing each of the items in turn and see what it is that is putting you over the top!